PW03-026 - Caspase-1 variants involved in ER stress
نویسندگان
چکیده
Introduction Caspase-1 is a proinflammatory enzyme that is activated by the NLRP3 inflammasome in response to endoplasmic reticulum (ER) stress independent of the classical unfolded protein response. This finding linked ER stress to chronic inflammatory diseases. In patients suffering from unexplained recurrent febrile episodes we detected several genetic variants of CASP1 leading to reduced enzymatic activity due to destabilization of the caspase-1 dimer interface.
منابع مشابه
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عنوان ژورنال:
دوره 11 شماره
صفحات -
تاریخ انتشار 2013